S. Sdelci

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

Comprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells

The paper identifies widespread metabolic enzyme localization on chromatin in healthy and cancer cells, showing tissue-specific abundance and non-canonical roles in DNA damage and repair.

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

Nuclear MTHFD2 secures mitosis progression by preserving centromere integrity

This study shows that nuclear MTHFD2 is essential for mitosis by maintaining centromere integrity and preventing chromosomal abnormalities in cancer cells.

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

This study shows that inhibiting LOXL2 and BRD4 together reduces triple-negative breast cancer proliferation by disrupting the BRD4S-LOXL2-MED1 interaction that controls cell cycle gene expression.

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.