Author

R. H. Chapple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

P. Geeleher· 3 shared A. G. Patel· 2 shared H. Sheppard· 2 shared H.-M. Lee· 2 shared J. Easton· 2 shared M. Pan· 2 shared W. C. Wright· 2 shared X. Liu· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

P. Geeleher

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3 papers

Recent·Most cited

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

A. G. Patel, O. Ashenberg, N. B. Collins, A. Segerstolpe, S. Jiang, M. Slyper, X. Huang, C. Caraccio, H. Jin, H. Sheppard, K. Xu, T.-C. Chang, B. A. Orr, A. Shirinifard, R. H. Chapple, , S. J. Rodig

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

bioRxiv · Jan 7, 2024 · PreprintCancer Biology

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.

R. H. Chapple, X. Liu, S. Natarajan, M. I. M. Alexander, Y. Kim, A. G. Patel, C. W. LaFlamme, M. Pan, W. C. Wright, H.-M. Lee, Y. Zhang, M. Lu, S. C. Koo, C. Long, J. Harper, , P. Geeleher

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

bioRxiv · Apr 13, 2023Cancer Biology

A CRISPR-drug perturbational map for identifying new compounds to combine with commonly used chemotherapeutics.

H.-M. Lee, W. C. Wright, M. Pan, J. Low, D. Currier, J. Fang, S. Singh, S. Nance, I. Delahunty, Y. Kim, R. H. Chapple, Y. Zhang, X. Liu, J. A. Steele, J. Qi, , P. Geeleher

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

bioRxiv · Apr 12, 2023Cancer Biology