Author

A. G. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:scRNA-seq· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2

Frequent Co-Authors

M. A. Dyer· 3 shared A. Karlstrom· 2 shared B. A. Orr· 2 shared C. Reilly· 2 shared E. Stewart· 2 shared H. Sheppard· 2 shared M. R. Clay· 2 shared P. Geeleher· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

M. A. Dyer

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Author profile →

5 papers

Recent·Most cited

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

A. G. Patel, O. Ashenberg, N. B. Collins, A. Segerstolpe, S. Jiang, M. Slyper, X. Huang, C. Caraccio, H. Jin, H. Sheppard, K. Xu, T.-C. Chang, B. A. Orr, A. Shirinifard, R. H. Chapple, , S. J. Rodig

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

bioRxiv · Jan 7, 2024 · PreprintCancer Biology

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

S. G. Danielli, Y. Wei, M. A. Dyer, E. Stewart, M. Wachtel, B. W. Schaefer, A. G. Patel, D. M. Langenau

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

bioRxiv · Oct 13, 2023Cancer Biology

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.

R. H. Chapple, X. Liu, S. Natarajan, M. I. M. Alexander, Y. Kim, A. G. Patel, C. W. LaFlamme, M. Pan, W. C. Wright, H.-M. Lee, Y. Zhang, M. Lu, S. C. Koo, C. Long, J. Harper, , P. Geeleher

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

bioRxiv · Apr 13, 2023Cancer Biology

Ly-6A-Induced Growth Inhibition and Cell death in a Transformed CD4+ T cell line: Role of Tumor Necrosis Factor-α (TNF-α)

A. G. Patel, S. Moxham, A. K. Bamezai

This study shows that Ly-6A engagement on CD4+ T cells induces apoptosis and growth inhibition via TNF-α, while antigen receptor stimulation leads to different cytokine profiles.

bioRxiv · Nov 16, 2021Immunology

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

A. G. Patel, X. Chen, X. Huang, M. R. Clay, N. Komarova, M. J. Krasin, A. Pappo, H. Tillman, B. A. Orr, J. McEvoy, B. Gordon, K. Blankenship, C. Reilly, X. Zhou, J. L. Norrie, , M. A. Dyer

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

bioRxiv · Jun 16, 2021Cancer Biology