Author

R. J. de Groot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:cryo-EM· 2 Approach:mechanistic / dynamical model· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

F. J. M. van Kuppeveld· 4 shared D. L. Hurdiss· 3 shared Y. Lang· 3 shared B.-J. Bosch· 2 shared I. Drulyte· 2 shared J. Snijder· 2 shared M. F. Pronker· 2 shared Z. Li· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

F. J. M. van Kuppeveld

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

C. Aloise, J. G. Schipper, A. van Vliet, J. Oymans, T. Donselaar, D. L. Hurdiss, R. J. de Groot, F. J. M. van Kuppeveld

This study identifies the SARS-CoV-2 nucleocapsid protein's N2b domain as inhibiting PKR-mediated integrated stress response and innate immunity by sequestering dsRNA.

PLOS Pathogens · Aug 22, 2023Peer-reviewedMicrobiology

Sialoglycan binding triggers spike opening in a human coronavirus

M. F. Pronker, R. Creutznacher, I. Drulyte, R. J. G. Hulswit, Z. Li, F. J. M. van Kuppeveld, J. Snijder, Y. Lang, B.-J. Bosch, G.-J. Boons, M. Frank, R. J. de Groot, D. L. Hurdiss

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

bioRxiv · Apr 20, 2023Microbiology

Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

Y. Lang, W. Li, Z. Li, D. Koerhuis, A. C. S. van den Burg, E. Rozemuller, B.-J. Bosch, F. J. M. van Kuppeveld, G.-J. P. H. Boons, E. G. Huizinga, H. M. van der Schaar, R. J. de Groot

The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.

Proceedings of the National Academy of Sciences · Sep 29, 2020Peer-reviewedMicrobiology

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

D. L. Hurdiss, I. Drulyte, Y. Lang, T. M. Shamorkina, M. F. Pronker, F. J. M. van Kuppeveld, J. Snijder, R. J. de Groot

The paper presents the cryo-EM structure of HKU1 HE, revealing structural changes due to prolonged human circulation, including a truncated lectin domain and intact esterase domain.

Nature Communications · Sep 16, 2020Peer-reviewedMicrobiology