Author

T. Donselaar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

D. L. Hurdiss· 3 shared F. J. M. van Kuppeveld· 3 shared A. Aggarwal· 1 shared A. Brancale· 1 shared A. L. W. van Vliet· 1 shared A. Norman· 1 shared A. van Vliet· 1 shared B. Canard· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

D. L. Hurdiss

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

C. Aloise, J. G. Schipper, A. van Vliet, J. Oymans, T. Donselaar, D. L. Hurdiss, R. J. de Groot, F. J. M. van Kuppeveld

This study identifies the SARS-CoV-2 nucleocapsid protein's N2b domain as inhibiting PKR-mediated integrated stress response and innate immunity by sequestering dsRNA.

PLOS Pathogens · Aug 22, 2023Peer-reviewedMicrobiology

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

V. Thijssen, D. L. Hurdiss, O. J. Debski-Antoniak, M. A. Spence, C. Franck, A. Norman, A. Aggarwal, N. J. Mokiem, D. A. A. van Dongen, S. W. Vermeir, M. Liu, W. Li, M. Chatziandreou, T. Donselaar, W. Du, , S. A. K. Jongkees

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

bioRxiv · Nov 11, 2022 · PreprintBiochemistry

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

D. L. Hurdiss, P. El Kazzi, L. Bauer, N. Papageorgiou, F. P. Ferron, T. Donselaar, A. L. W. van Vliet, B. Canard, E. Decroly, A. Brancale, T. Zeev-Ben-Mordehai, F. Förster, F. J. M. van Kuppeveld, B. Coutard

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

bioRxiv · Apr 26, 2021Microbiology