Author

R. J. Ladak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

N. Sonenberg· 2 shared S. M. Jafarnejad· 2 shared T. Duchaine· 2 shared X. Zhang· 2 shared A. Pistofidis· 1 shared A.-C. Gingras· 1 shared G. G. Hesketh· 1 shared J. Luo· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

N. Sonenberg

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Author profile →

2 papers

Recent·Most cited

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

J.-H. Choi, J. Luo, G. G. Hesketh, S. Guo, A. Pistofidis, R. J. Ladak, Y. An, T. Alain, M. Schmeing, A.-C. Gingras, T. Duchaine, X. Zhang, N. Sonenberg, S. M. Jafarnejad

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

bioRxiv · Oct 14, 2023Cell Biology

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

P. Naeli, X. Zhang, P. Harris Snell, S. Chatterjee, M. Kamran, R. J. Ladak, N. Orr, T. Duchaine, N. Sonenberg, S. M. Jafarnejad

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

bioRxiv · Jan 1, 2023Cell Biology