Author

G. G. Hesketh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:wet-lab / biochemical assay· 2

Frequent Co-Authors

A.-C. Gingras· 6 shared A. Pistofidis· 1 shared B. T. Emmer· 1 shared C. V. Robinson· 1 shared C. Zhang· 1 shared D. Ginsburg· 1 shared D. Ng· 1 shared D. Wu· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersCell Biology

A.-C. Gingras

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6 papers

Recent·Most cited

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

J.-H. Choi, J. Luo, G. G. Hesketh, S. Guo, A. Pistofidis, R. J. Ladak, Y. An, T. Alain, M. Schmeing, A.-C. Gingras, T. Duchaine, X. Zhang, N. Sonenberg, S. M. Jafarnejad

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

bioRxiv · Oct 14, 2023Cell Biology

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

C. Zhang, M. Shafaq-Zadah, J. Pawling, G. G. Hesketh, D. Ng, E. Dransart, K. Pacholczyk, J. Longo, A.-C. Gingras, L. Z. Penn, L. Johannes, J. W. Dennis

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

bioRxiv · Nov 15, 2022 · PreprintCell Biology

CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Y. Z. Tan, Y. M. Abbas, J. Z. Wu, D. Wu, G. G. Hesketh, S. A. Bueler, A.-C. Gingras, C. V. Robinson, S. Grinstein, J. L. Rubinstein

The paper uses cryoEM to study endogenous V-ATPase interactions with mEAK-7 in porcine kidney, revealing structural insights and functional differences compared to yeast.

bioRxiv · Nov 3, 2021Biochemistry

Rag GTPases and Phosphatidylinositol 3-Phosphate Mediate Recruitment of the AP-5/SPG11/SPG15 Complex

M. S. Robinson, J. Hirst, G. G. Hesketh, A.-C. Gingras

The paper shows that AP-5/SPG11/SPG15 complex recruitment to late endosomes/lysosomes requires PI3P and Rag GTPases, linking it to mTORC1 pathway and autophagic lysosome reformation.

bioRxiv · Oct 27, 2020Cell Biology

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

B. T. Emmer, G. G. Hesketh, E. Kotnik, V. T. Tang, P. J. Lascuna, J. Xiang, A.-C. Gingras, X.-W. Chen, D. Ginsburg

This study identifies SURF4 as a cargo receptor that facilitates PCSK9 secretion by linking it to COPII components and confirming its functional role through multiple experimental approaches.

bioRxiv · May 31, 2018Cell Biology

Proteomic and biochemical comparison of the cellular interaction partners of human VPS33A and VPS33B

M. R. Hunter, G. G. Hesketh, A.-C. Gingras, S. C. Graham

This study compares the interactomes of VPS33A and VPS33B using BioID, revealing distinct interaction partners and subcellular localization.

bioRxiv · Dec 20, 2017Biochemistry