Author

J.-H. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:metagenomics· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Luo· 2 shared N. Sonenberg· 2 shared S. M. Jafarnejad· 2 shared T. Alain· 2 shared T. Duchaine· 2 shared X. Zhang· 2 shared A. C. H. Liu· 1 shared A. Garzia· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

J. Luo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

J.-H. Choi, J. Luo, G. G. Hesketh, S. Guo, A. Pistofidis, R. J. Ladak, Y. An, T. Alain, M. Schmeing, A.-C. Gingras, T. Duchaine, X. Zhang, N. Sonenberg, S. M. Jafarnejad

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

bioRxiv · Oct 14, 2023Cell Biology

Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

J. H. Jeong, S. Chokkakula, S. C. Min, B. Kim, W.-S. Choi, S. Oh, Y. S. Yun, D. H. Kang, O.-J. Lee, E.-G. Kim, J.-H. Choi, J.-Y. Lee, Y. K. Choi, Y. H. Baek, M.-S. Song

This paper evaluates combination antiviral therapies in SARS-CoV-2 infected mice, finding that nirmatrelvir and molnupiravir together significantly improve survival compared to monotherapies.

bioRxiv · Jun 27, 2022Microbiology

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse

S. Y. Y. Jhang, S.-H. Lee, E.-B. Lee, J.-H. Choi, S. Bang, M. Jeong, H.-H. Jang, H.-J. Kim, H.-J. Lee, H. C. Jeong, S. J. Lee

This study investigates the effects of Platycodon grandiflorum diets on gut microbiota and immune system in immunosuppressed mice, finding increased microbial abundance and immune-related biomarker changes.

bioRxiv · May 7, 2021Microbiology