Author

R. J. Nowak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

M. L. Fichtner· 3 shared P. Stathopoulos· 3 shared R. Jiang· 3 shared K. B. Hoehn· 2 shared K. C. O'Connor· 2 shared K. C. OConnor· 2 shared K. Takata· 2 shared A. Vincent· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

M. L. Fichtner

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4 papers

Recent·Most cited

Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases

C. Mandel-Brehm, M. L. Fichtner, R. Jiang, V. J. Winton, S. E. Vazquez, M. C. Pham, K. B. Hoehn, N. L. Kelleher, R. J. Nowak, S. H. Kleinstein, M. R. Wilson, J. L. DeRisi, K. C. OConnor

This study identifies elevated N-glycosylation in IgG variable regions in myasthenia gravis patients and shows it is not required for autoantigen binding.

bioRxiv · Mar 6, 2021Immunology

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development

M. L. Fichtner, C. Vieni, R. Redler, L. Kolich, R. Jiang, K. Takata, P. Stathopoulos, P. Suarez, R. J. Nowak, S. J. Burden, D. Ekiert, K. C. O'Connor

The paper investigates how self-antigen-driven affinity maturation contributes to the development of pathogenic monovalent IgG4 autoantibodies in myasthenia gravis, showing that high-affinity Fab-arm exchanged antibodies require specific mutations for pathogenic capacity.

bioRxiv · Mar 14, 2020Immunology

Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses

R. Jiang, M. L. Fichtner, K. B. Hoehn, P. Stathopoulos, R. J. Nowak, S. Kleinstein, K. C. OConnor

The paper identifies persistent autoantibody-producing B cell clones in rituximab-treated myasthenia gravis patients during relapses, showing incomplete B cell depletion.

bioRxiv · Jan 15, 2020Immunology

Isolation and characterization of rare circulating autoantibody-producing cells from patients with muscle-specific kinase myasthenia gravis

K. Takata, P. Stathopoulos, M. Cao, M. Mane-Damas, M. Fichtner, E. S. Benotti, L. Jacobson, P. Waters, S. R. Irani, P. Martinez-Martinez, D. Beeson, M. Losen, A. Vincent, R. J. Nowak, K. C. O'Connor

The paper isolates and characterizes MuSK-specific autoantibody-producing B cells from MuSK myasthenia gravis patients, generating monoclonal antibodies that reveal distinct binding specificities and functional effects on AChR clustering.

bioRxiv · Dec 13, 2018Immunology