Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases
C. Mandel-Brehm, M. L. Fichtner, R. Jiang, V. J. Winton, S. E. Vazquez, M. C. Pham, K. B. Hoehn, N. L. Kelleher, R. J. Nowak, S. H. Kleinstein, M. R. Wilson, J. L. DeRisi, K. C. OConnor
This study identifies elevated N-glycosylation in IgG variable regions in myasthenia gravis patients and shows it is not required for autoantigen binding.
bioRxiv · Mar 6, 2021Immunology