Author

R. Jansen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Dekker· 1 shared A. E. McKechnie· 1 shared A. Friskes· 1 shared A. Mulero-Sanchez· 1 shared A. Protheroe· 1 shared A. R. Bourne· 1 shared A. R. Ridley· 1 shared A. Ryan· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Dekker

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Author profile →

5 papers

Recent·Most cited

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

T. Engelgeh, J. Herrmann, R. Jansen, R. Muller, S. Halbedel

The paper identifies tartrolon B as an inducer of the timABR operon in L. monocytogenes, revealing its role in sensing and detoxifying this antibiotic produced by soil bacteria.

bioRxiv · Jul 27, 2023 · PreprintMicrobiology

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

M. H. Dias, A. Friskes, S. Wang, J. M. H. Fernandes Neto, F. v. Gemert, S. Mourragui, H. J. Kuiken, S. Mainardi, D. Alvarez-Villanueva, C. Lieftink, B. Morris, A. Dekker, E. v. Dijk, C. Papagianni, M. S. da Silva, , R. Bernards

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

bioRxiv · Feb 6, 2023Cancer Biology

Hot days are associated with short-term adrenocortical responses in a Southern African arid-zone passerine bird.

L. L. Moagi, A. R. Bourne, S. J. Cunningham, R. Jansen, C. A. Ngcamphalala, A. R. Ridley, A. E. McKechnie

This study links high daily temperatures to increased stress hormone levels in Southern pied babblers, indicating acute heat stress responses above 38°C.

bioRxiv · Feb 17, 2021Physiology

An integrative study of five biological clocks in somatic and mental health

R. Jansen, J. Verhoeven, L. K. Han, K. A. Aberg, E. van den Oord, Y. Milaneschi, B. W. Penninx

This study examines five biological clocks in ~3000 subjects, finding small correlations between clocks and highlighting the composite index as a better reflection of biological age.

bioRxiv · Jun 11, 2020Cell Biology

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

P. Zhang, I. Kitchen-Smith, L. Xiong, G. Stracquadanio, K. Brown, P. Richter, M. Wallace, E. Bond, N. Sahgal, S. Moore, S. Nornes, S. De Val, M. Surakhy, D. Sims, X. Wang, , G. Bond

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

bioRxiv · Nov 9, 2019Cancer Biology