S. Halbedel

Cytosolic factors controlling PASTA kinase-dependent ReoM phosphorylation

This study identifies GpsB as an activator of PrkA, a PASTA kinase, and shows that ReoM phosphorylation is regulated by growth phase and phosphatase PrpC, with MurA's conformation and interaction with ReoM playing a key role.

High density genomic surveillance and risk profiling of clinical Listeria monocytogenes subtypes in Germany, 2018-2021

The paper analyzes genomic data from Listeria monocytogenes isolates in Germany to identify virulent and hypovirulent clones and their epidemiological patterns.

ListiWiki: a database for the foodborne pathogen Listeria monocytogenes

ListiWiki is a database that provides comprehensive genomic and functional information on Listeria monocytogenes, including gene annotations, protein interactions, and structural data.

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

The paper identifies tartrolon B as an inducer of the timABR operon in L. monocytogenes, revealing its role in sensing and detoxifying this antibiotic produced by soil bacteria.

Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes

This study shows that EslB deficiency in Listeria monocytogenes leads to thinner peptidoglycan and increased negative surface charge, enhancing lysozyme sensitivity.

Listeria monocytogenes gene essentiality under laboratory conditions and during macrophage infection

This study identifies essential genes for Listeria monocytogenes growth in laboratory conditions and during macrophage infection using Tn-Seq.

MurA escape mutations uncouple peptidoglycan biosynthesis from PrkA signaling

The paper identifies murA escape mutations in L. monocytogenes that prevent proteolytic degradation of MurA, constitutively activating peptidoglycan biosynthesis and enhancing cephalosporin resistance.

PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM

The paper identifies ReoM as a PASTA-eSTK substrate in Listeria monocytogenes, showing its phosphorylation is essential for controlling MurA degradation via ClpCP protease.

Population structure-guided profiling of antibiotic resistance patterns in clinical Listeria monocytogenes isolates from Germany identifies pbpB3 alleles associated with low levels of cephalosporin resistance

The paper analyzes antibiotic resistance in Listeria monocytogenes isolates from Germany, identifying pbpB3 alleles linked to reduced cephalosporin resistance.

Cell shape and antibiotic resistance is maintained by the activity of multiple FtsW and RodA enzymes in Listeria monocytogenes

This study identifies multiple FtsW and RodA enzymes in Listeria monocytogenes that maintain cell shape and antibiotic resistance, with their expression regulated in response to beta-lactam antibiotics.

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes

This study identifies GpsB as a cytosolic adaptor that coordinates cell wall synthesis with the bacterial cell cycle by interacting with multiple enzymes and proteins.