Author

A. Friskes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

R. H. Medema· 2 shared A. Curinha· 1 shared A. Dekker· 1 shared A. J. Holland· 1 shared A. Mulero-Sanchez· 1 shared A. van Oudenaarden· 1 shared A. Vidal· 1 shared A. Villanueva· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

R. H. Medema

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome

A. Curinha, Z. Huang, T. Anglen, M. A. Strong, C. R. Gliech, C. E. Jewett, A. Friskes, A. J. Holland

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

bioRxiv · Mar 6, 2024Cell Biology

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

M. H. Dias, A. Friskes, S. Wang, J. M. H. Fernandes Neto, F. v. Gemert, S. Mourragui, H. J. Kuiken, S. Mainardi, D. Alvarez-Villanueva, C. Lieftink, B. Morris, A. Dekker, E. v. Dijk, C. Papagianni, M. S. da Silva, , R. Bernards

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

bioRxiv · Feb 6, 2023Cancer Biology

MND1 enables repair of two-ended DNA double-strand breaks

L. Koob, A. Friskes, L. van Bergen, F. M. Feringa, B. van den Broek, E. S. Koeleman, M. Schubert, V. A. Blomen, T. R. Brummelkamp, L. Krenning, R. H. Medema

This study shows MND1 facilitates repair of two-ended DNA double-strand breaks in somatic cells through homologous recombination, but not one-ended breaks, and its absence increases IR-induced toxicity.

bioRxiv · Aug 24, 2022 · PreprintCell Biology