Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
A. B. Klein, T. S. Nicolaisen, N. Ortenblad, K. D. Gejl, R. Jensen, A. M. Fritzen, E. L. Larsen, K. Karstoft, H. E. Poulsen, T. Morville, R. E. Sahl, J. W. Helge, J. Lund, S. Falk, M. Lyngbaek, , C. Clemmensen
The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.
bioRxiv · Oct 23, 2020Physiology