E. A. Richter

Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

This study characterizes the skeletal muscle arginine methylome in health and disease, revealing significant remodeling in ALS and identifying potential therapeutic targets.

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.

The role of group I p21-activated kinases in contraction-stimulated skeletal muscle glucose transport

This study investigates the role of group I p21-activated kinases (PAKs) in contraction-stimulated glucose transport in skeletal muscle, finding that PAK2, but not PAK1, contributes to this process in EDL muscle.

Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)-2, but not PAK1, in mouse skeletal muscle

This study investigates the role of PAK1 and PAK2 in insulin-stimulated glucose uptake in mouse skeletal muscle, finding that PAK2, not PAK1, contributes to this process.

Phosphoproteomic identification of Xin as a novel requirement for skeletal muscle disuse atrophy

This study identifies Xin as a novel protein involved in skeletal muscle disuse atrophy using phosphoproteomic analysis and confirms its regulation in mice and humans.

Housing temperature influences exercise training adaptations in mice

This study shows that housing mice at thermoneutral temperatures reduces exercise training benefits in metabolic parameters and tissue adaptations.

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.