Author

R. Jimenez-Saiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Jordana· 4 shared K. Bruton· 3 shared S. Waserman· 3 shared Y. Ellenbogen· 3 shared D. K. Chu· 2 shared J. F. Koenig· 2 shared M. E. Gordon· 2 shared P. Spill· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

M. Jordana

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

E. M. Garcia-Cuesta, P. Martinez, K. Selvaraju, G. Ulltjärn, A. M. Gomez Pozo, G. D'Agostino, S. Gardeta, A. Quijada-Freire, P. Blanco Gabella, C. Roca, D. del Hoyo, R. Jimenez-Saiz, A. Garcia-Rubia, B. Soler Palacios, P. Lucas, , M. Mellado

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

bioRxiv · Nov 19, 2023Cell Biology

Allergic inflammation triggers dyslipidemia via IgG signalling

N. Fernandez-Gallego, R. Castillo-Gonzalez, L. Moreno-Serna, A. J. Garcia-Civico, E. Sanchez-Martinez, C. Lopez-Sanz, A. L. Fontes, L. L. Pimentel, A. Gradillas, D. Obeso, R. Neuhaus, M. Ramirez-Huesca, I. Ruiz-Fernandez, E. Nunez-Borque, Y. R. Carrasco, , R. Jimenez-Saiz

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

bioRxiv · Aug 4, 2023Immunology

Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens

J. F. Koenig, A. K. Wade-Vallance, R. Jimenez-Saiz, K. Bruton, S. Gadkar, E. Grydziuszko, T. Walker, M. E. Gordon, S. Waserman, M. Jordana

This study shows that sequential switching through IgG1 is not essential for IgE affinity, anaphylaxis, or allergic memory in food allergies.

bioRxiv · May 27, 2023 · PreprintImmunology

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

K. Bruton, P. Spill, S. Vohra, O. Baribeau, S. Manzoor, S. Gadkar, M. Davidson, T. D. Walker, Y. Ellenbogen, A. Florescu, J. Wen, D. K. Chu, S. Waserman, R. Jimenez-Saiz, S. Epelman, , M. Jordana

The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.

bioRxiv · Mar 4, 2020 · PreprintImmunology

Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity

R. Jimenez-Saiz, V. C. Anipindi, H. Galipeau, Y. Ellenbogen, R. Chaudhary, J. F. Koenig, M. E. Gordon, T. D. Walker, T. S. Mandur, S. Abed, A. Humbles, D. K. Chu, J. Erjefalt, K. Ask, E. F. Verdu, M. Jordana

This study shows that gut microbes regulate intestinal eosinophils, affecting tissue repair and allergic responses to food.

bioRxiv · Sep 26, 2019Immunology

BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy: an ephemeral existence?

R. Jimenez-Saiz, Y. Ellenbogen, K. Bruton, P. Spill, D. D. Sommer, H. Lima, S. Waserman, S. U. Patil, W. G. Shreffler, M. Jordana

The study identifies IgE+ memory B cells in humans as rare and suggests their limited clinical utility in allergic disease.

bioRxiv · Jan 3, 2019 · PreprintImmunology