M. Jordana

Pathogenic IgE-fated memory B cell responses retain functional plasticity

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.

Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens

This study shows that sequential switching through IgG1 is not essential for IgE affinity, anaphylaxis, or allergic memory in food allergies.

A Distinct Phenotype of Polarized Memory B cell holds IgE Memory

The paper identifies a novel memory B cell subset, MBC2s, that holds allergen-specific IgE memory and contributes to IgE production in allergic diseases.

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.

Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity

This study shows that gut microbes regulate intestinal eosinophils, affecting tissue repair and allergic responses to food.

BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy: an ephemeral existence?

The study identifies IgE+ memory B cells in humans as rare and suggests their limited clinical utility in allergic disease.