Author

S. Manzoor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Tan· 2 shared L. Broadbent· 2 shared A. Ali· 1 shared A. Bush· 1 shared A. Custovic· 1 shared A. Florescu· 1 shared A. M. Sidebottom· 1 shared B. Marsland· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

A. Tan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis

N. Fei, B. Xie, T. J. Long, M. StGeorge, A. Tan, S. Manzoor, A. M. Sidebottom, M. Melanie Spedale, B. R. Betty R Theriault, D. S. Dinanath Sulakhe, E. B. B.

This study shows that host-specific microbiota are essential for maintaining diet-specific metabolic homeostasis, while foreign microbiota impair metabolic fitness in germ-free mice.

bioRxiv · Nov 5, 2023 · PreprintMicrobiology

Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism

K. Frazier, S. Manzoor, K. Carroll, O. DeLeon, S. Miyoshi, J. Miyoshi, M. St George, A. Tan, M. Izumo, J. S. Takahashi, M. C. Rao, V. A. Leone, E. B. Chang

This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.

bioRxiv · May 24, 2022 · PreprintPhysiology

An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

L. Broadbent, C. G. G. Bamford, G. Lopez Campos, S. Manzoor, D. Courtney, A. Ali, O. Touzelet, C. McCaughey, K. Mills, U. Power

The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.

bioRxiv · Aug 17, 2021Immunology

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

K. Bruton, P. Spill, S. Vohra, O. Baribeau, S. Manzoor, S. Gadkar, M. Davidson, T. D. Walker, Y. Ellenbogen, A. Florescu, J. Wen, D. K. Chu, S. Waserman, R. Jimenez-Saiz, S. Epelman, , M. Jordana

The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.

bioRxiv · Mar 4, 2020 · PreprintImmunology

Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media.

L. Broadbent, S. Manzoor, M. Zarcone, J. Barabas, M. Shields, S. Saglani, C. M. Lloyd, A. Bush, A. Custovic, P. Ghazal, M. Gore, B. Marsland, G. Roberts, J. Schwarze, S. Turner, U. F. Power

This study compares two commercial media for culturing primary nasal epithelial cells and evaluates their impact on cell morphology, physiology, and RSV infection outcomes.

bioRxiv · Jan 13, 2020Cell Biology