Author

R. L. Stanfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. A. Ferguson· 2 shared X. Sun· 2 shared B. I. Leach· 1 shared G. Ward· 1 shared H. J. Dyson· 1 shared I. A. Wilson· 1 shared J. Dyson· 1 shared J. Han· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

J. A. Ferguson

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimers

Y.-Z. Lee, J. Han, Y.-N. Zhang, G. Ward, K. B. Gomes, S. Auclair, R. L. Stanfield, L. He, I. A. Wilson, J. Zhu

The study analyzes metastability in fusion proteins of RSV and hMPV to design stable uncleaved prefusion-closed trimers for vaccine development.

bioRxiv · Mar 7, 2024 · PreprintMicrobiology

Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

X. Sun, J. A. Ferguson, K. Yang, R. L. Stanfield, J. Dyson, P. Wright

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

bioRxiv · Feb 26, 2024Biophysics

Probing the dissociation pathway of a kinetically labile transthyretin mutant

X. Sun, J. A. Ferguson, B. I. Leach, R. L. Stanfield, H. J. Dyson, P. E. Wright

This study investigates the dissociation pathway of a kinetically labile transthyretin mutant using NMR and MD simulations to quantify the energy landscape at neutral pH.

bioRxiv · Jun 21, 2023Biophysics