Author

J. A. Ferguson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

X. Sun· 3 shared B. I. Leach· 2 shared J. Dyson· 2 shared P. Wright· 2 shared R. L. Stanfield· 2 shared A. B. Ward· 1 shared B. Greenhouse· 1 shared C. B. Bau· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

X. Sun

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

X. Sun, J. A. Ferguson, K. Yang, R. L. Stanfield, J. Dyson, P. Wright

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

bioRxiv · Feb 26, 2024Biophysics

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

B. I. Leach, J. A. Ferguson, G. J. Morgan, X. Sun, G. Kroon, D. Oyen, J. Dyson, P. Wright

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

bioRxiv · Feb 16, 2024Biophysics

Broadly inhibitory antibodies against severe malaria virulence proteins

R. A. Reyes, S. S. R. Raghavan, N. K. Hurlburt, V. Introini, I. H. Kana, R. W. Jensen, E. Martinez-Scholze, M. Gestal-Mato, C. B. Bau, M. L. Fernandez-Quintero, J. R. Loeffler, J. A. Ferguson, W.-H. Lee, G. M. Martin, T. G. Theander, , T. Lavstsen

The paper identifies two human monoclonal antibodies that broadly inhibit PfEMP1's binding to EPCR, a key process in severe malaria pathogenesis.

bioRxiv · Jan 25, 2024Immunology

Probing the dissociation pathway of a kinetically labile transthyretin mutant

X. Sun, J. A. Ferguson, B. I. Leach, R. L. Stanfield, H. J. Dyson, P. E. Wright

This study investigates the dissociation pathway of a kinetically labile transthyretin mutant using NMR and MD simulations to quantify the energy landscape at neutral pH.

bioRxiv · Jun 21, 2023Biophysics