J. E. Ussher

MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

The paper identifies SQSTM1/p62 as an MR1 interacting protein and shows its role in regulating MAIT cell activation through autophagy pathways.

Neutrophils Suppress Mucosal-Associated Invariant T Cells

This study shows neutrophils suppress MAIT cell activation via cell-contact and H2O2, while activated MAIT cells induce neutrophil death through TNF, revealing a bidirectional regulatory feedback loop.

Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation

This study shows that type I interferons enhance TCR-mediated MAIT cell activation by boosting cytokine and granzyme B production.

Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response

This study compares the transcriptional and effector responses of human MAIT cells to TCR and cytokine stimulation, revealing distinct functional outcomes.

Role of Innate-like Lymphocytes in the Pathogenesis of Community Acquired Pneumonia

This study examines the role of innate-like lymphocytes in community-acquired pneumonia, finding that their abundance correlates with clinical outcomes and immune responses.