Author

R. Leone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Brendolan· 1 shared A. Esposito· 1 shared A. J. Tam· 1 shared A. Monestiroli· 1 shared A. Thomas· 1 shared B. Alvarez-Moya· 1 shared B. Ferrini· 1 shared B. S. Slusher· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. Brendolan

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Author profile →

3 papers

Recent·Most cited

Tumor-Specific CD8+ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes

E. M. Zawidzka, L. Biavati, A. Thomas, C. L. Zanettini, L. Marchionni, R. Leone, I. Borrello

This study compares tumor-specific CD8+ T cells from the bone marrow with tumor-infiltrating lymphocytes, finding BM T cells to be more effective in persistence and function for adoptive cell therapy.

bioRxiv · Aug 28, 2023Immunology

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

N. L. Tran, L. M. Ferreira, B. Alvarez-Moya, V. Buttiglione, B. Ferrini, P. Zordan, A. Monestiroli, C. Fagioli, E. Bezzecchi, G. M. Scotti, A. Esposito, R. Leone, C. Gnasso, A. Brendolan, L. G. Guidotti, G. Sitia

The paper shows that continuous IFNα infusion reduces CRC liver metastasis by acting on hepatic endothelial cells to create an antimetastatic vascular barrier.

bioRxiv · May 10, 2022Cancer Biology

Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

M.-H. Oh, I.-H. Sun, L. Zhao, R. Leone, I.-M. Sun, W. Xu, S. L. Collins, A. J. Tam, R. L. Blosser, C. H. Patel, J. Englert, M. L. Arwood, J. Wen, Y. Chan-Li, P. Majer, , J. D. Powell

This study shows that targeting glutamine metabolism in tumors reduces MDSC generation, increases inflammatory macrophages, and enhances anti-tumor immunity, making checkpoint-resistant tumors responsive to immunotherapy.

bioRxiv · Jun 3, 2019 · PreprintImmunology