Author

A. J. Tam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Pena· 1 shared A. Ruta· 1 shared B. S. Slusher· 1 shared B. Yang· 1 shared C. Cherry· 1 shared C. H. Patel· 1 shared D. M. Pardoll· 1 shared D. R. Maestas· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioengineering

A. Pena

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

J. Han, C. Cherry, J. C. Mejias, A. Ruta, D. R. Maestas, A. Pena, H. H. Nguyen, B. Yang, E. Gray-Gaillard, N. Rutkowski, K. Krishnan, A. J. Tam, E. J. Fertig, F. Housseau, S. Ganguly, , J. H. Elisseeff

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

bioRxiv · Aug 17, 2021 · PreprintBioengineering

Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

M.-H. Oh, I.-H. Sun, L. Zhao, R. Leone, I.-M. Sun, W. Xu, S. L. Collins, A. J. Tam, R. L. Blosser, C. H. Patel, J. Englert, M. L. Arwood, J. Wen, Y. Chan-Li, P. Majer, , J. D. Powell

This study shows that targeting glutamine metabolism in tumors reduces MDSC generation, increases inflammatory macrophages, and enhances anti-tumor immunity, making checkpoint-resistant tumors responsive to immunotherapy.

bioRxiv · Jun 3, 2019 · PreprintImmunology