Author

B. S. Slusher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

R. Rais· 3 shared J. D. Powell· 2 shared L. Zhao· 2 shared P. Majer· 2 shared A. Amor-Coarasa· 1 shared A. G. Thomas· 1 shared A. J. Tam· 1 shared A. K. Jayabalan· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

R. Rais

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

S. Parveen, J. Shen, S. Lun, L. Zhao, B. Koleske, R. D. Leone, R. Rais, J. D. Powell, J. R. Murphy, B. S. Slusher, W. R. Bishai

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

High-throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain

M. A. Dasovich, J. Zhuo, A. G. Thomas, J. A. Goodman, R. L. McPherson, A. K. Jayabalan, V. F. Busa, S.-J. Cheng, B. Murphy, K. R. Redinger, T. Tsukamoto, B. S. Slusher, J. Bosch, J. Wei, A. Leung

The paper develops a high-throughput assay for screening inhibitors of the SARS-CoV-2 Mac1 macrodomain and identifies dasatinib and dihydralazine as inhibitors with selectivity over human MacroD2.

bioRxiv · Oct 7, 2021Biochemistry

Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms

T. Arab, E. R. Mallick, Y. Huang, L. Dong, Z. Liao, Z. Zhao, O. Gololobova, B. Smith, N. J. Haughey, K. J. Pienta, B. S. Slusher, P. M. Tarwater, J. P. Tosar, A. M. Zivkovic, W. N. Vreeland, , K. W. Witwer

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

bioRxiv · Aug 4, 2020Cell Biology

Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

M.-H. Oh, I.-H. Sun, L. Zhao, R. Leone, I.-M. Sun, W. Xu, S. L. Collins, A. J. Tam, R. L. Blosser, C. H. Patel, J. Englert, M. L. Arwood, J. Wen, Y. Chan-Li, P. Majer, , J. D. Powell

This study shows that targeting glutamine metabolism in tumors reduces MDSC generation, increases inflammatory macrophages, and enhances anti-tumor immunity, making checkpoint-resistant tumors responsive to immunotherapy.

bioRxiv · Jun 3, 2019 · PreprintImmunology

JHU-2545 Selectively Shields Salivary Glands and Kidneys during PSMA-Targeted Radiotherapy

M. T. Nedelcovych, R. P. Dash, Y. Wu, E. Y. Choi, R. S. Lapidus, P. Majer, D. Abou, M.-F. Penet, A. Nikolopoulou, A. Amor-Coarasa, J. Babich, D. L. Thorek, R. Rais, C. Kratochwil, B. S. Slusher

This paper describes the development of JHU-2545, a prodrug that selectively shields salivary glands and kidneys from PSMA-targeted radiotherapy, improving safety without affecting tumor uptake.

bioRxiv · Feb 15, 2019 · PreprintPharmacology & Toxicology