Author

T. C. Sutton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

D. R. Patel· 4 shared C. J. Field· 3 shared D. R. Perez· 2 shared G. Geiger· 2 shared K. M. Septer· 2 shared L. M. Ferreri· 2 shared A. Bhagwat· 1 shared A. C. Hurt· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

D. R. Patel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

D. R. Patel, A. M. Minns, D. G. Sims, C. J. Field, A. E. Kerr, T. Heinly, E. H. Luley, R. M. Rossi, C. Bator, I. M. Mostafa, S. L. Hafenstein, S. E. Lindner, T. C. Sutton

This paper develops an intranasal nanoparticle vaccine against SARS-CoV-2 using a SpyCage scaffold decorated with RBD, showing enhanced viral clearance in Syrian hamsters without preventing infection.

bioRxiv · Oct 27, 2022Immunology

Vitamin D and the ability to produce 1,25(OH)2D are critical for protection from viral infection of the lungs.

J. Arora, D. R. Patel, M. J. Nicol, C. J. Field, K. H. Restori, J. Wang, N. E. Froelich, B. Katkere, J. A. Terwilliger, V. Weaver, E. Luley, K. Kelly, G. S. Kirimanjeswara, T. C. Sutton, M. T.-A. Cantorna

This study shows that vitamin D deficiency worsens lung inflammation during H1N1 and SARS-CoV-2 infections, while sufficient vitamin D reduces inflammation, though not viral replication.

bioRxiv · Jun 29, 2022Immunology

Transmission of human influenza A virus in pigs selects for adaptive mutations on the HA gene

J.-s. Mo, E. J. Abente, T. C. Sutton, L. M. Ferreri, G. Geiger, P. C. Gauger, D. R. Perez, A. L. Vincent, D. S. Rajao

This study shows that human-origin influenza A viruses can transmit in pigs and select for adaptive mutations in the HA gene that improve replication and fitness in swine hosts.

bioRxiv · Apr 4, 2022Microbiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Transmission and protection against re-infection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate

D. R. Patel, C. J. Field, K. M. Septer, D. G. SIm, M. J. Jones, T. A. Heinly, E. A. McGraw, T. C. Sutton

This study evaluates transmission modes and immunity duration against SARS-CoV-2 in ferrets, finding direct contact transmission is efficient and immunity lasts at least 56 days, but intramuscular vaccination does not prevent upper respiratory tract infection.

bioRxiv · Nov 20, 2020Microbiology