A. Gontu

Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle

This study evaluates serological assays for SARS-CoV-2 in US cattle, finding no evidence of natural infection or transmission and highlighting issues with false positives in neutralization assays.

Adaptation-proof SARS-CoV-2 vaccine design

This study designs SARS-CoV-2 vaccines targeting conserved spike protein regions to reduce mutation escape, using epitope grafting on diverse scaffolds and showing immune response and diagnostic utility.

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

The paper introduces a CNN model to predict RBD-hACE2 binding affinity changes for SARS-CoV-2 variants, achieving high accuracy and identifying variants with improved binding affinity.

Detection of SARS-CoV-2 Omicron variant (B.1.1.529) infection of white-tailed deer

The paper shows SARS-CoV-2 Omicron variant infects white-tailed deer on Staten Island, with age-dependent antibody prevalence and evidence of human-to-deer spillover.

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike protein and the human ACE2 receptor

The paper predicts the effect of amino acid changes on SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics and a neural network, achieving 82.2% classification accuracy and 0.69 correlation with experimental data.

Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy

The study evaluates anti-SARS-CoV-2 antibody and neutralizing titer profiles in convalescent plasma samples to determine the optimal donation window for immunotherapy.

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.