A. Zimmer

FAAH Inhibition as a Path to Mitigate Alzheimer's Disease Progression in Mouse Models of Amyloidosis

This study shows FAAH inhibition improves cognitive symptoms and reduces amyloid in AD mouse models by enhancing AEA signaling and suppressing BACE1.

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

Genomic and Transcriptomic Profiling of Phoenix Colonies

This study investigates the genomic and transcriptomic changes in phoenix colonies and VBNC-like colonies of Pseudomonas aeruginosa in response to aminoglycoside exposure.

Adherent and suspension baby hamster kidney cells have a different cytoskeleton and surface receptor repertoire

The paper compares adherent and suspension BHK cells to identify differences in cytoskeleton and surface receptors, highlighting the importance of parental clones in adaptation.

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

This study shows that neuronal and lymphoid CB2 receptors work together to protect against neuropathic pain by reducing spontaneous and evoked pain behaviors in mice.

Actinobacillus utilizes a binding-protein dependent ABC transporter to acquire Vitamin B6

The paper identifies a Vitamin B6 uptake system in Actinobacillus using a binding-protein dependent ABC transporter, validated through structural and biochemical methods.

Universal cancer tasks, evolutionary tradeoffs, and the functions of driver mutations

The paper introduces a theoretical framework to understand tumor diversity by identifying universal cancer tasks and showing driver mutations influence gene-expression specialization.