Author

S. Wernig-Zorc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. J. Drake· 1 shared A. Thakker· 1 shared A. Tsakiridis· 1 shared A. Wenninger-Weinzierl· 1 shared B. Lucendo Villarin· 1 shared C. Hafemeister· 1 shared C. Ludwig· 1 shared C. Souilhol· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. J. Drake

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3 papers

Recent·Most cited

The long non-coding RNA MALAT1 modulates NR4A1 expression through a downstream regulatory element in specific cancer-cell-types

S. Wernig-Zorc, U. Schwartz, G. Laengst, R. Maldonado

This study identifies MALAT1's role in regulating NR4A1 expression via a downstream regulatory element in specific cancer cell types using RNA- and ATAC-seq.

bioRxiv · Mar 9, 2023Cell Biology

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

I. M. Saldana-Guerrero, L. F. Montano-Gutierrez, K. Boswell, C. Hafemeister, E. Poon, L. E. Shaw, D. Stavish, R. A. Lea, S. Wernig-Zorc, E. Bozsaky, I. S. Fetahu, P. Zoescher, U. Pötschger, M. Bernkopf, A. Wenninger-Weinzierl, , F. Halbritter

The paper uses human embryonic stem cells to show that chromosomal gains in neuroblastoma impair neural crest development and enhance MYCN-driven tumourigenesis.

bioRxiv · Nov 21, 2022Cancer Biology

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles, S. Wernig-Zorc, J. P. Thomson, P. D. Walker, A. Thakker, G. G. Lavery, C. Ludwig, D. A. Tennant, D. C. Hay, A. J. Drake

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

bioRxiv · Jun 23, 2020Biochemistry