Cancer BiologybioRxiv
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
P. C. Moore, J. Y. Qi, M. Thamsen…·S. A. Oakes
This study shows that targeting the UPR components IRE1α and PERK can inhibit pancreatic neuroendocrine tumor growth by inducing apoptosis through reciprocal signaling.
DOI 10.1158/0008-5472.can-19-1116