Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
P. C. Moore, J. Y. Qi, M. Thamsen, R. Ghosh, J. Peng, M. J. Gliedt, R. Meza-Acevedo, R. E. Warren, A. Hiniker, G. E. Kim, D. J. Maly, B. J. Backes, F. R. Papa, S. A. Oakes
This study shows that targeting the UPR components IRE1α and PERK can inhibit pancreatic neuroendocrine tumor growth by inducing apoptosis through reciprocal signaling.
bioRxiv · Sep 18, 2019Cancer Biology