Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions
K. Sugita, I. Onishi, R. Nakayama, S. Ishibashi, M. Ikeda, M. Inoue, R. Narita, S. Oshima, K. Shimizu, S. Saito, S. Sato, B. S. Moriarity, K. Yamamoto, D. Largaespada, M. Kitagawa, M. Kurata
This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.
bioRxiv · Jul 15, 2022Cancer Biology