Author

R. Nencka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

E. Boura· 2 shared A. Aspuru-Guzik· 1 shared A. Fortova· 1 shared A. Huskova· 1 shared A. Kundaje· 1 shared A. Nigam· 1 shared A. Piralla· 1 shared B. Cihlova· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

E. Boura

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

A. Nigam, M. F. D. Hurley, F. Li, E. Konkolova, M. Klima, J. Trylcova, R. Pollice, S. S. Cınaroglu, R. Levin-Konigsberg, J. Handjaya, M. Schapira, I. Chau, S. Perveen, H.-L. Ng, H. U. Kaniskan, , A. Aspuru-Guzik

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

bioRxiv · Oct 3, 2023 · PreprintBiochemistry

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

R. De Gasparo, M. Pedotti, L. Simonelli, P. Nickl, F. Muecksch, I. Cassaniti, E. Percivalle, J. C. C. Lorenzi, F. Mazzola, D. Magri, T. Michalcikova, J. Haviernik, V. Honig, B. Mrazkova, N. Polakova, , T. Hatziioannou

bioRxiv · Jan 22, 2021 · PreprintImmunology

High-throughput fluorescent assay for inhibitor screening of proteases from RNA viruses

B. Cihlova, A. Huskova, J. Böserle, R. Nencka, E. Boura, J. Silhan

The paper develops a high-throughput fluorescent assay for screening protease inhibitors from RNA viruses and validates it for SARS-CoV-2 and tick-borne encephalitis virus.

bioRxiv · Oct 27, 2020Biochemistry

Viral RNA-dependent RNA polymerase inhibitor 7-deaza-2′-C-methyladenosine prevents death in a mouse model of West Nile virus infection

L. Eyer, M. Fojtikova, R. Nencka, I. Rudolf, Z. Hubalek, D. Ruzek

This study shows that 7-deaza-2'-C-methyladenosine protects mice from West Nile virus infection, reducing mortality even when treatment starts 3 days post-infection.

bioRxiv · Oct 2, 2018Microbiology