Author

D. Ruzek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:long-read sequencing· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Kakuk· 2 shared D. Tombacz· 2 shared G. E. Toth· 2 shared G. Gulyas· 2 shared G. Kemenesi· 2 shared I. Prazsak· 2 shared J. Holoubek· 2 shared L. Eyer· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

B. Kakuk

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Exploring the Transcriptomic Profile of Human Monkeypox Virus via CAGE and Native RNA Sequencing Approaches

Z. Boldogkoi, G. A. Nagy, D. Tombacz, I. Prazsak, Z. Csabai, A. Dörmo, G. Gulyas, G. Kemenesi, G. E. Toth, J. Holoubek, D. Ruzek, B. Kakuk

This study uses CAGE and long-read RNA sequencing to analyze the transcriptional architecture of human monkeypox virus, identifying alternative TSSs, TESs, promoter elements, and novel genes.

bioRxiv · Apr 29, 2024Microbiology

The structure of immature tick-borne encephalitis virus

M. Anastasina, T. Fuzik, A. Domanska, L. I. A. Pulkkinen, L. Smerdova, P. P. Formanova, P. Strakova, J. Novacek, D. Ruzek, P. Plevka, S. J. Butcher

This study determines the structure of immature TBEV using cryoEM, revealing the organization of surface glycoproteins and the role of prM cleavage in viral maturation.

bioRxiv · Aug 4, 2023 · PreprintMicrobiology

In-depth Temporal Transcriptome Profiling of Monkeypox and Host Cells using Nanopore Sequencing

B. Kakuk, A. Dormo, Z. Csabai, G. Kemenesi, J. Holoubek, D. Ruzek, I. Prazsak, V. E. Dani, B. Denes, G. Torma, F. Jakab, G. E. Toth, F. V. Foldes, B. Zana, Z. Lanszki, , Z. Boldogkoi

This study uses Oxford Nanopore long-read RNA-Sequencing to profile the transcriptome of monkeypox virus and host cells, revealing gene expression dynamics and host transcriptomic changes.

bioRxiv · Nov 28, 2022Microbiology

Low-pathogenic virus induced immunity against TBEV protects mice from disease but not from virus entry into the CNS

M. Petry, M. Palus, E. Leitzen, J. G. Mitterreiter, B. Huang, A. Kröger, G. M. G. M. Verjans, W. Baumgärtner, G. F. Rimmelzwaan, D. Ruzek, A. Osterhaus, C. Prajeeth

This study shows that pre-infection with low-virulent or avirulent TBEV strains protects mice from lethal TBEV-Hypr infection but allows virus entry into the CNS.

bioRxiv · Jan 11, 2021 · PreprintImmunology

Bcr-Abl tyrosine kinase inhibitor imatinib as a potential drug for COVID-19

N. S. Mulgaonkar, H. Wang, S. Mallawarachchi, D. Ruzek, B. Martina, S. Fernando

This paper reports that imatinib, an FDA-approved Bcr-Abl inhibitor, inhibits SARS-CoV-2 and other coronaviruses by blocking viral membrane fusion, suggesting its potential as a repurposed drug for COVID-19.

bioRxiv · Jun 18, 2020Microbiology

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

L. Eyer, A. Nougairede, M. Uhlirova, J.-S. Driouich, D. Zouharova, J. J. Valdes, J. Haviernik, E. A. Gould, E. De Clercq, X. de Lamballerie, D. Ruzek

This paper identifies an E460D substitution in TBEV RdRp that confers resistance to Galidesivir and attenuates the virus in mice.

bioRxiv · Feb 28, 2019Microbiology

Viral RNA-dependent RNA polymerase inhibitor 7-deaza-2′-C-methyladenosine prevents death in a mouse model of West Nile virus infection

L. Eyer, M. Fojtikova, R. Nencka, I. Rudolf, Z. Hubalek, D. Ruzek

This study shows that 7-deaza-2'-C-methyladenosine protects mice from West Nile virus infection, reducing mortality even when treatment starts 3 days post-infection.

bioRxiv · Oct 2, 2018Microbiology