Author

R. Levin-Konigsberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Kundaje· 2 shared A. Nigam· 2 shared K. Spees· 2 shared M. C. Bassik· 2 shared A. Aspuru-Guzik· 1 shared A. M. Wehman· 1 shared A. R. Krishnan· 1 shared A. R. Mantegazza· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. Kundaje

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

A. Nigam, M. F. D. Hurley, F. Li, E. Konkolova, M. Klima, J. Trylcova, R. Pollice, S. S. Cınaroglu, R. Levin-Konigsberg, J. Handjaya, M. Schapira, I. Chau, S. Perveen, H.-L. Ng, H. U. Kaniskan, , A. Aspuru-Guzik

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

bioRxiv · Oct 3, 2023 · PreprintBiochemistry

SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter

R. Levin-Konigsberg, K. Mitra, A. Nigam, K. Spees, P. Hivare, K. Liu, A. Kundaje, Y. Krishnan, M. Bassik

This study identifies SLC12A9 as a lysosomal ammonium exporter that maintains lysosomal homeostasis by transporting ammonium and chloride.

bioRxiv · May 22, 2023 · PreprintCell Biology

A lysosomal lipid transport pathway that enables cell survival under cholinelimitation

S. G. Scharenberg, W. Dong, K. Nyame, R. Levin-Konigsberg, A. R. Krishnan, E. S. Rawat, K. Spees, M. C. Bassik, M. Abu-Remaileh

This study identifies SPNS1 as a critical lysosomal transporter for choline recycling under limitation, revealing a novel pathway for phospholipid salvage and cell survival.

bioRxiv · Nov 27, 2022 · PreprintCell Biology

TORC1, BORC, ARL-8 cycling, and kinesin-1 drive vesiculation of cell corpsephagolysosomes

G. Fazeli, R. Levin-Konigsberg, M. C. Bassik, C. Stigloher, A. M. Wehman

The paper identifies a molecular pathway involving TORC1, BORC, ARL-8, and kinesin-1 that drives phagolysosome vesiculation for efficient cell corpse clearance in C. elegans and mammals.

bioRxiv · Feb 9, 2022Cell Biology

Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells

C. Lopez-Haber, R. Levin-Konigsberg, Y. Zhu, J. Bi-Karchin, T. Balla, S. Grinstein, M. S. Marks, A. R. Mantegazza

This study identifies PI4KII as essential for phagosomal TLR4 signaling and MHC-II presentation in dendritic cells by facilitating TIRAP recruitment.

bioRxiv · Jan 22, 2020Cell Biology