RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma
T. Naert, D. Dimitrakopoulou, D. Tulkens, S. Demuynck, R. Noelanders, L. Eeckhout, G. Van Isterdael, D. Deforce, C. Vanhove, J. Van Dorpe, D. Creytens, K. Vleminckx
This study uses CRISPR/Cas9 in Xenopus tropicalis to show that RBL1/p107 compensates for RB1 loss in driving specific cancers like SC-PaNEC and retinoblastoma.
bioRxiv · Jan 23, 2019Cancer Biology