Author

K. Vleminckx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:Xenopus· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Creytens· 3 shared D. Tulkens· 3 shared S. Demuynck· 3 shared C. Vanhove· 2 shared D. Dimitrakopoulou· 2 shared T. Naert· 2 shared T. Van Nieuwenhuysen· 2 shared B. Alman· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

D. Creytens

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3 papers

Recent·Most cited

Engraftment of allotransplantated tumour cells in adult rag2 mutant Xenopus tropicalis

D. Tulkens, D. Dimitrakopoulou, T. Van Nieuwenhuysen, M. Boelens, S. Demuynck, W. Toussaint, D. Creytens, P. Van Vlierberghe, K. Vleminckx

This paper establishes a Xenopus tropicalis model for studying human cancer by generating a rag2-/- knock-out line and optimizing irradiation protocols for tumor cell engraftment.

bioRxiv · Nov 15, 2021 · PreprintCancer Biology

CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

T. Naert, D. Tulkens, T. Van Nieuwenhuysen, J. Przybyl, S. Demuynck, M. van de Rijn, M. Al Jazrawe, B. Alman, P. J. Coucke, K. De Leeneer, C. Vanhove, S. N. Savvides, D. Creytens, K. Vleminckx

This paper introduces CRISPR-SID, a method to identify tumor dependencies in Xenopus models, revealing EZH2 as a druggable target for desmoid tumors.

bioRxiv · Sep 1, 2021Cancer Biology

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma

T. Naert, D. Dimitrakopoulou, D. Tulkens, S. Demuynck, R. Noelanders, L. Eeckhout, G. Van Isterdael, D. Deforce, C. Vanhove, J. Van Dorpe, D. Creytens, K. Vleminckx

This study uses CRISPR/Cas9 in Xenopus tropicalis to show that RBL1/p107 compensates for RB1 loss in driving specific cancers like SC-PaNEC and retinoblastoma.

bioRxiv · Jan 23, 2019Cancer Biology