Author

J. Van Dorpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

D. Creytens· 2 shared A. Dickmanns· 1 shared A. Filosa· 1 shared A. Jochemsen· 1 shared A. Louwagie· 1 shared A. Van Parys· 1 shared B. De Paepe· 1 shared B. Decaesteker· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

D. Creytens

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

S. De Munter, J. Buhl, L. De Cock, A. Van Parys, W. Daneels, E. Pascal, L. Deseins, J. Ingels, G. Goetgeluk, L. Billiet, M. Pille, N. Vandamme, J. Van Dorpe, F. Offner, E. Depla, , B. Vandekerckhove

The paper shows that knocking out CD70 in CD70-specific nanoCAR T cells improves their functionality in vivo by preventing antigen-induced exhaustion.

bioRxiv · Jan 22, 2023Immunology

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

S. Dewaele, L. Delhaye, B. De Paepe, E. De Bony, J. De Wilde, K. Vanderheyden, J. Anckaert, N. Yigit, E. VandenEynde, F. Nemati, D. Decaudin, A. Jochemsen, E. Leucci, J. Vandesompele, J. Van Dorpe, , P. Mestdagh

This study shows that inhibiting the lncRNA SAMMSON reduces uveal melanoma cell growth and viability by impairing mitochondrial function and protein translation.

bioRxiv · Jan 18, 2021Cancer Biology

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma

B. Decaesteker, A. Louwagie, S. Loontiens, F. De Vloed, J. Roels, S. Vanhauwaert, S. De Brouwer, E. Sanders, G. Denecker, E. D'haene, S. Van Haver, W. Van Loocke, J. Van Dorpe, D. Creytens, N. Van Roy, , F. Speleman

This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.

bioRxiv · Aug 21, 2020 · PreprintCancer Biology

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

E. De Thaye, K. Van de Vijver, J. Van der Meulen, J. Taminau, G. Wagemans, H. Denys, J. Van Dorpe, G. Berx, W. Ceelen, J. Van Bocxlaer, O. De Wever

The paper establishes and characterizes a PDX model and cell line from peritoneal metastasis of low-grade serous ovarian carcinoma, showing sensitivity to paclitaxel and trametinib.

bioRxiv · Sep 27, 2019Cancer Biology

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma

T. Naert, D. Dimitrakopoulou, D. Tulkens, S. Demuynck, R. Noelanders, L. Eeckhout, G. Van Isterdael, D. Deforce, C. Vanhove, J. Van Dorpe, D. Creytens, K. Vleminckx

This study uses CRISPR/Cas9 in Xenopus tropicalis to show that RBL1/p107 compensates for RB1 loss in driving specific cancers like SC-PaNEC and retinoblastoma.

bioRxiv · Jan 23, 2019Cancer Biology

Mutations in nucleoporin NUP88 cause lethal neuromuscular disorder

E. Bonnin, P. Cabochette, A. Filosa, R. Juehlen, S. Komatsuzaki, M. Hezwani, A. Dickmanns, V. Martinelli, M. Vermeersch, L. Supply, N. Martins, L. Pirenne, G. Ravenscroft, M. Lombard, S. A. Port, , B. Fahrenkrog

This study identifies biallelic NUP88 mutations as a cause of lethal fetal akinesia deformation sequence (FADS) and shows their effects on neuromuscular development in zebrafish and human cells.

bioRxiv · Aug 14, 2018Cell Biology