Author

D. Deforce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

F. Van Nieuwerburgh· 5 shared B. Decaesteker· 3 shared C. Van Neste· 3 shared F. Speleman· 3 shared K. Durinck· 3 shared L. M. Mus· 3 shared E. Sanders· 2 shared H. De Kort· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

F. Van Nieuwerburgh

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Author profile →

7 papers

Recent·Most cited

Non-random polymorphisms near transposable elements facilitate evolution across the genome of Arabidopsis thaliana

H. De Kort, Y. Gansemans, D. Deforce, F. Van Nieuwerburgh

This study analyzes 973 Arabidopsis thaliana genomes to show that transposable elements (TEs) drive non-random genetic variation and contribute to evolutionary potential despite self-fertilization.

bioRxiv · Oct 24, 2023 · PreprintEvolutionary Biology

An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia

L. Provez, B. Van Puyvelde, L. Corveleyn, N. Demeulemeester, S. Verhelst, B. Lintermans, S. Daled, J. Roels, L. Clement, L. Martens, D. Deforce, P. Van Vlierberghe, M. Dhaenens

The paper presents a comprehensive mass spectrometry-based atlas of histone posttranslational modifications in T-cell acute lymphoblastic leukemia cell lines, providing a reusable dataset for epidrug development.

bioRxiv · May 5, 2022Cancer Biology

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

S. Zanotti, S. Vanhauwaert, C. Van Neste, V. Olexiouk, J. Van Laere, M. Verschuuren, L. M. Mus, K. Durinck, L. Tilleman, D. Deforce, F. Van Nieuwerburgh, M. D. Hogarty, B. Decaesteker, W. H. De Vos, F. Speleman

This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.

bioRxiv · Jan 22, 2021Cancer Biology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

L. M. Mus, S. Van Haver, M. Popovic, W. Trypsteen, S. Lefever, N. Zeltner, Y. Ogando, E. Z. Jacobs, G. Denecker, E. Sanders, C. Van Neste, S. Vanhauwaert, B. Decaesteker, D. Deforce, F. Van Nieuwerburgh, , F. Speleman

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

bioRxiv · Nov 6, 2020Cancer Biology

Ecological divergence of DNA methylation patterns at distinct spatial scales

H. De Kort, B. Panis, D. Deforce, F. Van Nieuwerburgh, O. Honnay

This study investigates how DNA methylation patterns diverge across spatial scales in Fragaria vesca plants, finding that epigenetic memories form at fine scales and are influenced by both parallel and non-parallel biological processes.

bioRxiv · Nov 7, 2019 · PreprintEcology

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma

T. Naert, D. Dimitrakopoulou, D. Tulkens, S. Demuynck, R. Noelanders, L. Eeckhout, G. Van Isterdael, D. Deforce, C. Vanhove, J. Van Dorpe, D. Creytens, K. Vleminckx

This study uses CRISPR/Cas9 in Xenopus tropicalis to show that RBL1/p107 compensates for RB1 loss in driving specific cancers like SC-PaNEC and retinoblastoma.

bioRxiv · Jan 23, 2019Cancer Biology