CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping
T. Naert, D. Tulkens, T. Van Nieuwenhuysen, J. Przybyl, S. Demuynck, M. van de Rijn, M. Al Jazrawe, B. Alman, P. J. Coucke, K. De Leeneer, C. Vanhove, S. N. Savvides, D. Creytens, K. Vleminckx
This paper introduces CRISPR-SID, a method to identify tumor dependencies in Xenopus models, revealing EZH2 as a druggable target for desmoid tumors.
bioRxiv · Sep 1, 2021Cancer Biology