Author

T. L. Putoczki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1

Frequent Co-Authors

K. Y. Fung· 2 shared M. D. W. Griffin· 2 shared A. L. Garnham· 1 shared A. M. Olthof· 1 shared A. P. Leis· 1 shared A. Preaudet· 1 shared A. W. Burgess· 1 shared B. B. Williams· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

K. Y. Fung

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3 papers

Recent·Most cited

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

R. D. Metcalfe, E. Hanssen, K. Y. Fung, K. Aizel, C. C. Kosasih, C. O. Zlatic, L. Doughty, C. J. Morton, A. P. Leis, M. W. Parker, P. R. Gooley, T. L. Putoczki, M. D. W. Griffin

This study presents cryo-EM and crystal structures of the IL-11 signalling complex, revealing dynamics of gp130 and the inhibitory mechanism of a cytokine variant.

bioRxiv · Jul 21, 2022Cell Biology

TGF-beta1 induced S100 family protein expression is associated with epithelial to mesenchymal transition states and poor survival in pancreatic cancer

R. R. J. Low, K. Y. Fung, H. Gao, A. Preaudet, L. F. Dagley, J. Yousef, B. Lee, R. H. Larsen, N. J. Kershaw, A. W. Burgess, P. Gibbs, F. Hollande, M. D. W. Griffin, S. M. Grimmond, T. L. Putoczki

The paper links TGF-beta1-induced S100 family protein expression to EMT states and poor survival in pancreatic cancer using a murine organoid biobank.

bioRxiv · Feb 25, 2022 · PreprintCancer Biology

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

K. Doggett, K. J. Morgan, S. Mieruszynski, B. B. Williams, A. M. Olthof, A. L. Garnham, M. J. G. Milevskiy, L. Whitehead, J. Coates, M. Buchert, R. J. O'Donoghue, T. E. Hall, Z. Gong, T. L. Putoczki, M. Ernst, , J. K. Heath

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

bioRxiv · Dec 9, 2021Cancer Biology