Realtime 2-5A kinetics suggests interferons β and {lambda} evade global arrest of translation by RNase L
A. Chitrakar, S. Rath, J. Donovan, K. Demarest, Y. Li, R. Rao Sridhar, S. Weiss, S. Kotenko, N. Wingreen, A. Korennykh
The paper develops a biosensor to study 2-5A kinetics and shows that interferons β and λ evade RNase L-mediated translation arrest during the innate immune response.
bioRxiv · Nov 26, 2018Cell Biology