A. Korennykh

Cryo-EM Structure of HRSL Domain Reveals Activating Crossed Helices at the Core of GCN2

The paper reports a cryo-EM structure of the HRSL domain from GCN2, revealing its role in activating the kinase and regulating the ISR pathway.

The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)

This study identifies NADP+ and NADPH as substrates of the circadian protein Nocturnin, showing its enzymatic activity in converting these metabolites and revealing structural insights into its mechanism.

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response

The paper investigates how 2-5A-mediated mRNA decay and transcription reprogram protein synthesis in response to dsRNA, showing that IFN-related mRNAs accumulate due to stability and feedback mechanisms.

Realtime 2-5A kinetics suggests interferons β and {lambda} evade global arrest of translation by RNase L

The paper develops a biosensor to study 2-5A kinetics and shows that interferons β and λ evade RNase L-mediated translation arrest during the innate immune response.

Crystal Structure of Human Nocturnin Catalytic Domain

The paper presents the crystal structure of the human Nocturnin catalytic domain and identifies structural differences from related deadenylases.

Y-RNA and tRNA Cleavage by RNase L Mediates Terminal dsRNA Response

The paper identifies RNase L as the enzyme responsible for cleaving Y-RNAs and tRNAs in response to dsRNA, with RNY1 depletion initiating apoptosis.