Author

K. Demarest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Korennykh· 2 shared J. Donovan· 2 shared N. Wingreen· 2 shared S. Rath· 2 shared A. Chitrakar· 1 shared E. Prangley· 1 shared R. Rao Sridhar· 1 shared S. Kotenko· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

A. Korennykh

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2 papers

Recent·Most cited

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response

S. Rath, E. Prangley, J. Donovan, K. Demarest, Y. Meir, N. Wingreen, A. Korennykh

The paper investigates how 2-5A-mediated mRNA decay and transcription reprogram protein synthesis in response to dsRNA, showing that IFN-related mRNAs accumulate due to stability and feedback mechanisms.

bioRxiv · Dec 4, 2018Cell Biology

Realtime 2-5A kinetics suggests interferons β and {lambda} evade global arrest of translation by RNase L

A. Chitrakar, S. Rath, J. Donovan, K. Demarest, Y. Li, R. Rao Sridhar, S. Weiss, S. Kotenko, N. Wingreen, A. Korennykh

The paper develops a biosensor to study 2-5A kinetics and shows that interferons β and λ evade RNase L-mediated translation arrest during the innate immune response.

bioRxiv · Nov 26, 2018Cell Biology