Author

J. Donovan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Korennykh· 3 shared S. Rath· 3 shared K. Demarest· 2 shared N. Wingreen· 2 shared A. Chitrakar· 1 shared D. Kolet-Mandrikov· 1 shared E. Prangley· 1 shared R. Rao Sridhar· 1 shared

Activity by Year

2016-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

A. Korennykh

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3 papers

Recent·Most cited

Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response

S. Rath, E. Prangley, J. Donovan, K. Demarest, Y. Meir, N. Wingreen, A. Korennykh

The paper investigates how 2-5A-mediated mRNA decay and transcription reprogram protein synthesis in response to dsRNA, showing that IFN-related mRNAs accumulate due to stability and feedback mechanisms.

bioRxiv · Dec 4, 2018Cell Biology

Realtime 2-5A kinetics suggests interferons β and {lambda} evade global arrest of translation by RNase L

A. Chitrakar, S. Rath, J. Donovan, K. Demarest, Y. Li, R. Rao Sridhar, S. Weiss, S. Kotenko, N. Wingreen, A. Korennykh

The paper develops a biosensor to study 2-5A kinetics and shows that interferons β and λ evade RNase L-mediated translation arrest during the innate immune response.

bioRxiv · Nov 26, 2018Cell Biology

Y-RNA and tRNA Cleavage by RNase L Mediates Terminal dsRNA Response

J. Donovan, S. Rath, D. Kolet-Mandrikov, A. Korennykh

The paper identifies RNase L as the enzyme responsible for cleaving Y-RNAs and tRNAs in response to dsRNA, with RNY1 depletion initiating apoptosis.

bioRxiv · Nov 10, 2016Immunology