D. Parker

The Staphylococcus aureus small non-coding RNA IsrR regulates TCA cycle activity and virulence

This study shows that the small non-coding RNA IsrR in S. aureus regulates TCA cycle activity and virulence by controlling acnA expression and Fe uptake.

Digital twinning of cardiac electrophysiology for congenital heart disease

The paper develops a computational pipeline to create digital twins of cardiac electrophysiology for pediatric congenital heart disease patients using BLNMs to match clinical ECGs.

Development of an MR-guided focused ultrasound (MRgFUS) lesioning approach for small and deep structures in the rat brain

This paper develops an MR-guided focused ultrasound lesioning method for small and deep brain structures in rats, achieving improved targeting accuracy.

YlaN is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

This study identifies YlaN as an Fe(II) binding protein in S. aureus that relieves Fur-mediated repression of gene expression during Fe deprivation.

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

CrOssing fiber Modeling in the Peritumoral Area using dMRI (COMPARI)

This paper introduces COMPARI, a new multi-compartment model for dMRI that improves fiber tract visualization in brain tumor peritumoral regions by removing isotropic components like free water.

Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields

The paper introduces TiGGER, a time-resolved EPR method at high magnetic fields, to study protein mechanical dynamics, finding that light activation causes rapid separation and slow relaxation in AsLOV2.

Fine-tuned repression of Drp1 driven mitochondrial fission primes a slow cycling stem/progenitor-like state towards accelerating neoplastic transformation of keratinocytes

The paper shows that fine-tuned Drp1 repression primes keratinocytes for neoplastic transformation by maintaining a stem/progenitor-like state with elevated stem markers and Cyclin E.

Staphylococcal DNA repair is required for infection

This study identifies DNA repair mechanisms in Staphylococcus aureus essential for survival during infection, showing that host immune cells induce DNA damage repaired by RexAB.

Freewater EstimatoR using iNtErpolated iniTialization (FERNET): Toward Accurate Estimation of Free Water in Peritumoral Region Using Single-Shell Diffusion MRI Data

FERNET improves free water estimation in peritumoral regions using single-shell diffusion MRI data, enhancing tractography in brain tumor patients.

Mito-SinCe2 Approach to Quantify Relationships between Mitochondrial Dynamics and Energetics status

The paper develops and validates mito-SinCe2, an approach to quantify the relationship between mitochondrial dynamics and energetics, revealing distinct states and linear relationships in ovarian tumor initiating cells.

Cerebral amyloid angiopathy and comparative analysis of amyloid-β protein in birds

The paper investigates the presence of cerebral amyloid angiopathy (CAA) and amyloid-β (Aβ) deposits in birds, finding CAA in an Amazon parrot and noting interspecific variation in Aβ deposition.