T. B. Clarke

Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites

This study shows antibiotics reduce gut commensals, enrich nutrients, and deplete metabolites, promoting CRE growth in the intestine.

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

Staphylococcal DNA repair is required for infection

This study identifies DNA repair mechanisms in Staphylococcus aureus essential for survival during infection, showing that host immune cells induce DNA damage repaired by RexAB.

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

This paper shows that Shigella sonnei's O-antigen mediates neutrophil tolerance and increases dysentery incidence in zebrafish, suggesting O-antigen as a therapeutic target.

MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation

This study identifies MUC5AC as a driver of COPD exacerbation severity by amplifying virus-induced airway inflammation through ATP release.