The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon beta.
J. D. O'Neil, O. O. Bolimowska, S. A. Clayton, T. Tang, K. K. Daley, S. Lara-Reyna, J. Warner, C. S. Martin, R. Y. Mahida, R. S. Hardy, S. Arthur, A. R. Clark
This study shows dexamethasone inhibits antiviral gene expression in macrophages by suppressing IFNβ expression and downstream interferon-regulated genes.
bioRxiv · May 3, 2023 · PreprintImmunology