Author

K. J. Bar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:rat· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

G. M. Shaw· 4 shared E. Lindemuth· 3 shared H. Li· 3 shared S. R. Permar· 3 shared A. I. Murphy· 2 shared A. N. Nelson· 2 shared B. F. Keele· 2 shared C. Chan· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

G. M. Shaw

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Assessing The Impact Of Autologous Neutralizing Antibodies On Viral Rebound In Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

E. Mainou, S. J. Berendam, V. Obregon-Perko, E. A. Uffman, C. T. Phan, G. M. Shaw, K. J. Bar, J. M. Conway, C. Chan, A. M. Chahroudi, J. McCarthy, S. R. Permar, G. Silvestri, R. F. Siliciano, J. Silicano, , M. R. Kumar

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

bioRxiv · Jul 22, 2023 · PreprintImmunology

Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques

A. Bauer, E. Lindemuth, J. Joy, F. E. Marino, S. S. Docken, R. Krause, S. Mallick, K. McCormick, C. Holt, I. Georgiev, B. K. Felber, B. F. Keele, R. Veazey, M. P. Davenport, H. Li, , K. J. Bar

This paper adapts a transmitted/founder SHIV to enhance replication in rhesus macaques while preserving HIV-1 Env biology, resulting in a more fit virus for NHP HIV studies.

bioRxiv · Dec 12, 2022Microbiology

Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir

V. H. Wu, S. Nguyen, J. M. L. Nordin, J. Joy, F. Mampe, P. Tebas, L. J. Montaner, K. J. Bar, L. A. Vella, M. R. Betts

This study identifies phenotypic and epigenetic heterogeneity in the HIV-1 infected CD4+ T cell reservoir using single-cell multiomic profiling of ART-treated individuals.

bioRxiv · Apr 2, 2022Microbiology

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

H. Li, S. Wang, F.-H. Lee, R. S. Roark, A. I. Murphy, J. Smith, C. Zhao, J. Rando, N. Chohan, Y. Ding, E. Kim, E. Lindemuth, K. J. Bar, I. Pandrea, C. Apetrei, , G. M. Shaw

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

bioRxiv · Jan 13, 2021Microbiology

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

R. S. Roark, H. Li, W. B. Williams, H. Chug, R. D. Mason, J. Gorman, S. Wang, F.-H. Lee, J. Rando, M. Bonsignori, K.-K. Hwang, K. O. Saunders, K. Wiehe, M. A. Moody, P. T. Hraber, , C. A Schramm

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

bioRxiv · Aug 5, 2020Immunology

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

R. Goswami, A. N. Nelson, J. J. Tu, M. Dennis, L. Feng, A. Kumar, J. Mangold, R. J. Mangan, C. Mattingly, A. D. Curtis, V. Obregon-Perko, M. Mavigner, J. Pollara, G. M. Shaw, K. J. Bar, , S. R. Permar

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

bioRxiv · Jun 11, 2019Immunology

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

A. N. Nelson, R. Goswami, M. Dennis, J. Tu, R. Mangan, P. T. Saha, D. W. Cain, X. Shen, G. M. Shaw, K. J. Bar, M. G. Hudgens, J. Pollara, K. De Paris, K. K. A. Van Rompay, S. R. Permar

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

bioRxiv · Feb 2, 2019Immunology