G. M. Shaw

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

Assessing The Impact Of Autologous Neutralizing Antibodies On Viral Rebound In Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

Longitudinal dynamics of the human vaginal ecosystem across the reproductive cycle

This study tracks changes in the vaginal microbiome and inflammation across the reproductive cycle, finding that childbirth disrupts microbial communities and reduces Lactobacillus dominance, with limited recovery over one year.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Quantitative LCMS for ceramides/dihydroceramides: pregnancy baseline biomarkers and potential metabolic messengers

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiome

This study uses metagenomic analysis with strain-level resolution to examine the human pregnancy microbiome, revealing gestational age and health complications influence microbial community composition and function.

Humans are colonized by many uncharacterized and highly divergent microbes

The paper identifies hundreds of new bacteria and viruses in the human microbiome using blood-based shotgun sequencing and validates their existence through independent experiments and PCR.