J. Zimmer

Structure, function and assembly of soybean primary cell wall cellulose synthases

This study characterizes the structure and function of soybean primary cell wall cellulose synthases, revealing their assembly and interaction mechanisms for cellulose biosynthesis.

Molecular insights into phosphoethanolamine cellulose formation and secretion

This study elucidates the molecular mechanism of phosphoethanolamine (pEtN) modification and secretion of cellulose in Enterobacteriaceae, identifying key protein interactions and enzymatic roles.

Complement-Activating Multimeric Immunotherapeutic Complexes for HER2-breast cancer immunotherapy

This study develops and tests CoMiX immunotherapeutics that activate complement to kill HER2-positive breast cancer cells, showing significant tumor growth inhibition in xenograft models.

Structural snapshots of hyaluronan formation reveal principles of length control and secretion

This study uses structural snapshots of HA-synthase to reveal mechanisms of HA length control and secretion.

Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8

This study presents cryo-EM structures of poplar cellulose synthase-8 with substrates and products, revealing substrate coordination and catalytic mechanisms.

Natural Killer activating Multimeric Immunotherapeutic compleXes (NaMiX) induce cytotoxic activity and killing of HIV-1 infected cells

This study develops NaMiX, multimeric immunotherapeutics targeting NK cell checkpoints, which enhance NK cell cytotoxicity against HIV-1 infected cells and reduce viral DNA in mice.

Genomic instability in patients with sex determination defects and germ cell cancer

This study identifies DNA damage phenotypes and TP53 mutations in DSD patients with germ cell tumors, linking genomic instability to infertility and cancer risk.

Dietary modulation alters susceptibility to Listeria monocytogenes and Salmonella typhimurium in a gut microbiota-independent manner

This study shows that a low-fiber diet reduces susceptibility to Listeria monocytogenes and Salmonella typhimurium in a microbiota-independent manner in gnotobiotic mice.

FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells

This study shows that FAM13A depletion increases KLRG1 and reduces IFN-gamma production in NK cells, leading to increased lung metastases in a mouse model.

Complementary α-arrestin - Rsp5 ubiquitin ligase complexes control selective nutrient transporter endocytosis in response to amino acid availability

The paper identifies complementary α-arrestin-Rsp5 complexes that regulate selective endocytosis of nutrient transporters based on amino acid availability.